Duration of untreated psychosis and outcomes

What is duration of untreated psychosis (DUP)?

DUP is generally determined as the time from the onset of psychotic symptoms to the initiation of treatment or first clinical presentation, when a diagnosis of first-episode psychosis may be given. Longer DUP has been associated with poorer prognosis and is thought to be a predictor of the likelihood and extent of recovery. As such, understanding the effects of DUP is particularly important because it is potentially modifiable.

What is the evidence for DUP and outcomes?

Moderate to high quality evidence indicates longer DUP, particularly over 9 months, is associated with more severe symptoms, including symptoms of depression and anxiety, and poor social and overall functioning, quality of life, and low response to treatment. Moderate quality evidence also suggests less likelihood of remission with a longer DUP. Effect sizes were all small to medium-sized.

Moderate quality evidence finds a large effect of increased risk of homicide, and a small effect of increased risk of deliberate self-harm with longer DUP.

Moderate quality evidence finds brain structural anomalies in people with first-episode psychosis are not consistently associated with length of DUP.

https://library.neura.edu.au/schizophrenia/illness-course-and-outcomes/duration-of-untreated-psychosis-outcomes/

One thought on “Duration of untreated psychosis and outcomes

Leave a Reply, All comments will be moderated - Many thanks for your contribution

Please log in using one of these methods to post your comment:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.