Testosterone and anabolic steroids have been found to affect the central nervous system in laboratory animals and humans. Their locations of affect in the brain are closely linked to centres that regulate mood, sexuality and aggression (1).
People who use steroids in excessive doses often experience, during the using period or after it, mood disorders that meet the criteria of psychiatric disease categories such as depression, anxiety, psychotic reactions and cognitive deterioration (2).
Anabolic steroids affect the brain neurotransmitter systems.
It has been studied that steroids affect the brain serotonin and dopamine neurotransmitter systems.
Dopamine is a multi-function neurotransmitter participating in the regulation of mobility, learning, emotions, appetite and positive reinforcing effects. It is an important neurotransmitter for operating the reward system, so dopamine is essential for addiction development. Serotonin, in turn, regulates sleep patterns, movement, appetite, sexuality and emotions. According to some studies, it is also related to memory operations and sustainable concentration.