Areas of the prefrontal cortex are important in monitoring our behavior, estimating consequences and incorporating emotional learning into our future decision-making process. If this area is deficient, this could mean that, for psychopaths, whatever they would learn through emotions would not affect future decisions and they may underestimate the consequences of their actions.
A section of the prefrontal cortex – the orbitofrontal cortex – shows reduced grey matter in volume and thickness. Again, the more severe the psychopathy, the greater this deficiency seems to be. The activation in this region during specific tasks mirrors this finding as when psychopaths decide to cooperate, they show less activation here and when they observe an opponent being punished, this area activates more than in the normal brain (which correlates with antisocial behavior and impulsivity traits).